Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5722843 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Wang Yanfei Y Li Jie J Yao Xuerui X Li Wei W Du Haibo H Tang Mingliang M Xiong Wei W Chai Renjie R Xu Zhigang Z
Frontiers in molecular neuroscience 20171204
Calcium and integrin-binding protein 2 (CIB2) belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Among the family members, the <i>Cib1</i> and <i>Cib2</i> genes are expressed in mouse cochlear hair cells, and mutations in the human <i>CIB2</i> gene have been associated with nonsyndromic deafness DFNB48 and syndromic deafness USH1J. To further explore the function of CIB1 and CIB2 in hearing, we established ...[more]