Promiscuity, impersonation and accommodation: evolution of plant specialized metabolism.
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ABSTRACT:
SUBMITTER: Leong BJ
PROVIDER: S-EPMC5723210 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Promiscuity, impersonation and accommodation: evolution of plant specialized metabolism.
Leong Bryan J BJ Last Robert L RL
Current opinion in structural biology 20170816
Specialized metabolic enzymes and metabolite diversity evolve through a variety of mechanisms including promiscuity, changes in substrate specificity, modifications of gene expression and gene duplication. For example, gene duplication and substrate binding site changes led to the evolution of the glucosinolate biosynthetic enzyme, AtIPMDH1, from a Leu biosynthetic enzyme. BAHD acyltransferases illustrate how enzymatic promiscuity leads to metabolite diversity. The examples 4-coumarate:CoA ligas ...[more]
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