Ontology highlight
ABSTRACT:
SUBMITTER: Murgai M
PROVIDER: S-EPMC5724390 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Murgai Meera M Ju Wei W Eason Matthew M Kline Jessica J Beury Daniel W DW Kaczanowska Sabina S Miettinen Markku M MM Kruhlak Michael M Lei Haiyan H Shern Jack F JF Cherepanova Olga A OA Owens Gary K GK Kaplan Rosandra N RN
Nature medicine 20170918 10
A deeper understanding of the metastatic process is required for the development of new therapies that improve patient survival. Metastatic tumor cell growth and survival in distant organs is facilitated by the formation of a pre-metastatic niche that is composed of hematopoietic cells, stromal cells and extracellular matrix (ECM). Perivascular cells, including vascular smooth muscle cells (vSMCs) and pericytes, are involved in new vessel formation and in promoting stem cell maintenance and prol ...[more]