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Age at onset and the outcomes of schizophrenia: A systematic review and meta-analysis.


ABSTRACT: The aim of this study was to analyse the effect of age at onset on the long-term clinical, social and global outcomes of schizophrenia through a systematic review and a meta-analysis. Original studies were searched from Web of Science, PsycINFO, Pubmed and Scopus, as well as manually. Naturalistic studies with at least a 2-year follow-up were included. Of the 3509 search results, 81 articles fulfilled the inclusion criteria. The meta-analysis was performed in Stata as a random-effect analysis with correlation coefficients between age at onset and the outcomes (categorized into remission, relapse, hospitalization, positive symptoms, negative symptoms, total symptoms, general clinical outcome, employment, social/occupational functioning and global outcome). There was a statistically significant (P?

SUBMITTER: Immonen J 

PROVIDER: S-EPMC5724698 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Age at onset and the outcomes of schizophrenia: A systematic review and meta-analysis.

Immonen Johanna J   Jääskeläinen Erika E   Korpela Hanna H   Miettunen Jouko J  

Early intervention in psychiatry 20170427 6


The aim of this study was to analyse the effect of age at onset on the long-term clinical, social and global outcomes of schizophrenia through a systematic review and a meta-analysis. Original studies were searched from Web of Science, PsycINFO, Pubmed and Scopus, as well as manually. Naturalistic studies with at least a 2-year follow-up were included. Of the 3509 search results, 81 articles fulfilled the inclusion criteria. The meta-analysis was performed in Stata as a random-effect analysis wi  ...[more]

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