CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome.
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ABSTRACT:
SUBMITTER: Rozen S
PROVIDER: S-EPMC5724754 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome.
Rozen Shelly S Füzesi-Levi Maria G MG Ben-Nissan Gili G Mizrachi Limor L Gabashvili Alexandra A Levin Yishai Y Ben-Dor Shifra S Eisenstein Miriam M Sharon Michal M
Cell reports 20151008 3
The highly conserved COP9 signalosome (CSN) complex is a key regulator of all cullin-RING-ubiquitin ligases (CRLs), the largest family of E3 ubiquitin ligases. Until now, it was accepted that the CSN is composed of eight canonical components. Here, we report the discovery of an additional integral and stoichiometric subunit that had thus far evaded detection, and we named it CSNAP (CSN acidic protein). We show that CSNAP binds CSN3, CSN5, and CSN6, and its incorporation into the CSN complex is m ...[more]
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