Ontology highlight
ABSTRACT:
SUBMITTER: Eckstrand KL
PROVIDER: S-EPMC5724830 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Eckstrand Kristen L KL Mummareddy Nishit N Kang Hakmook H Cowan Ronald R Zhou Minchun M Zald David D Silver Heidi J HJ Niswender Kevin D KD Avison Malcolm J MJ
PloS one 20171211 12
Central insulin resistance (IR) influences striatal dopamine (DA) tone, an important determinant of behavioral self-regulation. We hypothesized that an association exists between the degree of peripheral IR and impulse control, mediated by the impact of IR on brain circuits controlling the speed of executing "go" and/or "stop" responses. We measured brain activation and associated performance on a stop signal task (SST) in obese adults with type 2 diabetes (age, 48.1 ± 6.9 yrs (mean ± SD); BMI, ...[more]