Immunoparalysis in Pediatric Critical Care.
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ABSTRACT:
SUBMITTER: Hall MW
PROVIDER: S-EPMC5724958 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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Immunoparalysis in Pediatric Critical Care.
Hall Mark W MW Greathouse Kristin C KC Thakkar Rajan K RK Sribnick Eric A EA Muszynski Jennifer A JA
Pediatric clinics of North America 20170818 5
Although many forms of critical illness are initiated by a proinflammatory stimulus, a compensatory anti-inflammatory response can occur with systemic inflammation. Immunoparalysis, an important form of acquired immunodeficiency, affects the innate and adaptive arms of the immune system. Immunoparalysis has been associated with increased risks for nosocomial infection and death in a variety of pediatric critical illnesses. Evidence suggests that immunoparalysis is reversible with immunostimulant ...[more]
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