NAMPT overexpression induces cancer stemness and defines a novel tumor signature for glioma prognosis.
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ABSTRACT:
SUBMITTER: Lucena-Cacace A
PROVIDER: S-EPMC5725111 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
NAMPT overexpression induces cancer stemness and defines a novel tumor signature for glioma prognosis.
Lucena-Cacace Antonio A Otero-Albiol Daniel D Jiménez-García Manuel P MP Peinado-Serrano Javier J Carnero Amancio A
Oncotarget 20170828 59
Gliomas are the most prevalent primary malignant brain tumors associated with poor prognosis. NAMPT, a rate-limiting enzyme that boosts the nicotinamide adenine dinucleotide (NAD) regeneration in the salvage pathway, is commonly expressed in these tumors. NAD metabolism is required to maintain tissue homeostasis. To maintain metabolism, cancer cells require a stable NAD regeneration circuit. However, high levels of NAD confer resistance to therapy to these tumors, usually treated with Temozolomi ...[more]
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