Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid ?1-42 in Alzheimer's Disease Neuroimaging Initiative participants.

ABSTRACT: Introduction:Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease. Cerebrospinal fluid (CSF) amyloid ? (A?) 1-42 is an important Alzheimer's disease biomarker. However, it is inconclusive on how T2DM is related to CSF A?1-42. Methods:Participants with T2DM were selected from the Alzheimer's Disease Neuroimaging Initiative by searching keywords from the medical history database. A two-way analysis of covariance model was used to analyze how T2DM associates with CSF A?1-42 or cerebral cortical A?. Results:CSF A?1-42 was higher in the T2DM group than the nondiabetic group. The inverse relation between CSF A?1-42 and cerebral cortical A? was independent of T2DM status. Participants with T2DM had a lower cerebral cortical A? in anterior cingulate, precuneus, and temporal lobe than controls. Discussion:T2DM is positively associated with CSF A?1-42 but negatively with cerebral cortical A?. The decreased cerebral cortical A? associated with T2DM is preferentially located in certain brain regions.

SUBMITTER: Li W 

PROVIDER: S-EPMC5725206 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature