Ontology highlight
ABSTRACT:
SUBMITTER: Patel AR
PROVIDER: S-EPMC5725227 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Patel Apurva R AR Chougule Mahavir M Singh Mandip M
Pharmaceutical research 20140529 10
<h4>Purpose</h4>Evaluation of tumor targeting pegylated EphA2 peptide coated nanoparticles (ENDDs) of a novel anticancer agent DIM-C-pPhC6H5 (DIM-P) and Docetaxel (DOC) and investigate its antitumor activity and potential for treatment of lung cancer.<h4>Methods</h4>Nanoparticles were prepared with DIM-P and DOC (NDDs) using Nano-DeBEE. ENDDs were prepared by conjugating NDDs with 6His-PEG2K-EphA2 peptide and characterized for physicochemical properties, binding assay, cytotoxicity, cellular upt ...[more]