Ontology highlight
ABSTRACT:
SUBMITTER: Fang X
PROVIDER: S-EPMC5725374 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Fang Xue X Sun Dingya D Wang Zhihong Z Yu Zhongwang Z Liu Weili W Pu Yingyan Y Wang Dan D Huang Aijun A Liu Mingdong M Xiang Zhenghua Z He Cheng C Cao Li L
Neuroscience bulletin 20170717 6
Multiple sclerosis (MS) is a classical inflammatory demyelinating disease of the central nervous system (CNS). Microglia are the main resident immune cells in the CNS and are closely associated with the pathogenesis of MS. In the present study, we found that miR-30a was highly expressed in jellyfish-like microglia in chronic active lesions of MS patients, as well as in the microglia of mice with experimental autoimmune encephalomyelitis (EAE) at the chronic phase. In vitro, the conditioned super ...[more]