Ontology highlight
ABSTRACT:
SUBMITTER: Dubankova A
PROVIDER: S-EPMC5725453 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Scientific reports 20171211 1
Most single stranded plus RNA viruses hijack phosphatidylinositol 4-kinases (PI4Ks) to generate membranes highly enriched in phosphatidylinositol 4-phosphate (PI4P). These membranous compartments known as webs, replication factories or replication organelles are essential for viral replication because they provide protection from the innate intracellular immune response while serving as platforms for viral replication. Using purified recombinant proteins and biomimetic model membranes we show th ...[more]