Ontology highlight
ABSTRACT:
SUBMITTER: Malka Y
PROVIDER: S-EPMC5725528 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Malka Yuval Y Steiman-Shimony Avital A Rosenthal Eran E Argaman Liron L Cohen-Daniel Leonor L Arbib Eliran E Margalit Hanah H Kaplan Tommy T Berger Michael M
Nature communications 20171211 1
The majority of mammalian genes contain one or more alternative polyadenylation sites. Choice of polyadenylation sites was suggested as one of the underlying mechanisms for generating longer/shorter transcript isoforms. Here, we demonstrate that mature mRNA transcripts can undergo additional cleavage and polyadenylation at a proximal internal site in the 3'-UTR, resulting in two stable, autonomous, RNA fragments: a coding sequence with a shorter 3'-UTR (body) and an uncapped 3'-UTR sequence down ...[more]