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Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas.

ABSTRACT: Intraneural perineuriomas are benign peripheral nerve sheath tumors that cause progressive debilitating focal extremity weakness. The etiology of perineuriomas is largely unknown. We utilized whole exome sequencing, copy number algorithm evaluation, and high-resolution whole genome microarray to investigate for a genetic causal link to intraneural perineuriomas. Ten of 16 (60%) tumor cases had mutations in the WD40 domain of TRAF7, the same location for causal mutations of meningiomas. Two additional perineurioma cases had large chromosomal abnormalities in multiple chromosomes, including chromosome 22q. This study identifies a common cause for intraneural perineuriomas and an unexpected shared pathogenesis with intracranial meningiomas. Ann Neurol 2017;81:316-321.

SUBMITTER: Klein CJ

PROVIDER: S-EPMC5725965 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas.

Klein Christopher J CJ Wu Yanhong Y Jentoft Mark E ME Mer Georges G Spinner Robert J RJ Dyck P James B PJ Dyck Peter J PJ Mauermann Michelle L ML

Annals of neurology 20170128 2

Intraneural perineuriomas are benign peripheral nerve sheath tumors that cause progressive debilitating focal extremity weakness. The etiology of perineuriomas is largely unknown. We utilized whole exome sequencing, copy number algorithm evaluation, and high-resolution whole genome microarray to investigate for a genetic causal link to intraneural perineuriomas. Ten of 16 (60%) tumor cases had mutations in the WD40 domain of TRAF7, the same location for causal mutations of meningiomas. Two addit ...[more]

PMID: 28019650

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