Dataset Information

Effects of Prenatal PM₁₀ Exposure on Fetal Cardiovascular Malformations in Fuzhou, China: A Retrospective Case-Control Study.

ABSTRACT:

Background

Maternal exposure to ambient air pollution has been associated with an increased risk of congenital heart defects in offspring; however, the results are inconsistent.

Objectives

We investigated whether there is an association between prenatal exposure to particulate matter with diameter ?10?m (PM₁₀) during early pregnancy and fetal cardiovascular malformations.

Methods

The gravidae from a hospital-based case–control study in Fuzhou, China, during 2007–2013 were assigned 10-d or 1-mo averages of daily PM₁₀ using an air monitor–based inverse distance weighting method during early pregnancy. A total of 662 live-birth or selectively terminated cases and 3,972 live-birth controls were enrolled. The exposure was considered as a categorical variable. A multivariable logistic regression model was constructed to quantify the adjusted odds ratios (aORs) of the exposure to PM₁₀ and the risks of fetal cardiovascular malformations.

Results

PM₁₀ levels were positively associated with the risks of atrial septal defect (aORs ranging from 1.29 to 2.17), patent ductus arteriosus [aORs = 1.54, 1.63; 95% confidence intervals (CIs): 1.17, 2.23; 1.06, 3.24], overall fetal cardiovascular malformations (aOR = 1.28; 95% CI: 1.03, 1.61), ventricular septal defect (aOR = 1.19; 95% CI: 1.00, 1.43), and tetralogy of Fallot (aOR = 1.44; 95% CI: 1.01, 2.19) in the various observed periods scaled by 10 d or 1 mo in the first and second gestation months. The strongest associations were observed for exposure to PM₁₀ in the second quartile, whereas the associations were attenuated when higher concentrations of PM₁₀ in the third and fourth quartiles of the exposure were evaluated. No correlations of PM₁₀ levels with these cardiovascular malformations in the other time periods of gestation were observed.

Conclusions

Our findings suggest some positive associations between maternal exposure to ambient PM₁₀ during the first two months of pregnancy and fetal cardiovascular malformations. https://doi.org/10.1289/EHP289.

SUBMITTER: Liu CB

PROVIDER: S-EPMC5726369 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Publications

Effects of Prenatal PM<sub>10</sub> Exposure on Fetal Cardiovascular Malformations in Fuzhou, China: A Retrospective Case-Control Study.

Liu Chao-Bin CB Hong Xin-Ru XR Shi Miao M Chen Xiao-Qiu XQ Huang Hui-Juan HJ Chen Jin-Hua JH Yang Kai K Chen Su-Qing SQ Chen Han-Qiang HQ Kan Hai-Dong HD Sun Qing-Hua QH

Environmental health perspectives 20170525 5

<h4>Background</h4>Maternal exposure to ambient air pollution has been associated with an increased risk of congenital heart defects in offspring; however, the results are inconsistent.<h4>Objectives</h4>We investigated whether there is an association between prenatal exposure to particulate matter with diameter ≤10μm (PM<sub>10</sub>) during early pregnancy and fetal cardiovascular malformations.<h4>Methods</h4>The gravidae from a hospital-based case–control study in Fuzhou, China, during 2007– ...[more]

PMID: 28557713

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Project description:BackgroundChildhood exposure to air pollution has been linked with maladaptive cognitive development; however, less is known about the association between prenatal fine particulate matter (PM2.5) exposure and childhood behavior.ObjectivesOur aim was to assess the association between prenatal PM2.5 exposure and behavioral development in 4-6 year old children residing in Mexico City.MethodsWe used data from 539 mother-child pairs enrolled in a prospective birth cohort in Mexico City. We estimated daily PM2.5 exposure using a 1 km2 satellite-based exposure model and averaged over each trimester of pregnancy. We assessed childhood behavior at 4-6 years of age using the parent-completed Behavioral Assessment Scale for Children (BASC-2) composite scores and subscales. We used linear regression models to estimate change in BASC-2 T-scores with trimester specific 5-μg/m3 increases in PM2.5. All models were mutually adjusted for PM2.5 exposures during the other trimesters, maternal factors including age, education, socioeconomic status, depression, and IQ, child's age at study visit, and season. We additionally assessed sex-specific effects by including an interaction term between PM2.5 and sex.ResultsHigher first trimester PM2.5 exposure was associated with reduced Adaptive Skills scores (β: -1.45, 95% CI: -2.60, -0.30). Lower scores on the Adaptive Skills composite score and subscales indicate poorer functioning. For PM2.5 exposure during the first trimester, decrements were consistent across adaptive subscale scores including Adaptability (β: -1.51, 95% CI: -2.72, -0.30), Social Skills (β: -1.63, 95% CI: -2.90, -0.36), and Functional Communication (β: -1.21, 95% CI: -2.21, -0.21). The association between 1st trimester PM2.5 and depression was stronger in males than females (β for males: 1.52, 95% CI: -0.41, 3.45; β for females: -0.13, 95% CI: -1.99, 1.72; p-int: 0.07).ConclusionsExposure to PM2.5 during early pregnancy may be associated with impaired behavioral development in children, particularly for measures of adaptive skills. These results suggest that air pollution impacts behavioral domains as well as cognition, and that the timing of exposure may be critical.

Project description:BackgroundExposure to air pollution is associated with increased blood pressure (BP) in adults and children. Some evidence suggests that air pollution exposure during the prenatal period may contribute to adverse cardiorenal health later in life. Here we apply a distributed lag model (DLM) approach to identify critical windows that may underlie the association between prenatal particulate matter ? 2.5 ?m in diameter (PM2.5) exposure and children's BP at ages 4-6 years.MethodsParticipants included 537 mother-child dyads enrolled in the Programming Research in Obesity, GRowth Environment, and Social Stress (PROGRESS) longitudinal birth cohort study based in Mexico City. Prenatal daily PM2.5 exposure was estimated using a validated satellite-based spatio-temporal model and BP was measured using the automated Spacelabs system with a sized cuff. We used distributed lag models (DLMs) to examine associations between daily PM2.5 exposure and systolic and diastolic BP (SBP and DBP), adjusting for child's age, sex and BMI, as well as maternal education, preeclampsia and indoor smoking report during the second and third trimester, seasonality and average postnatal year 1 PM2.5 exposure.ResultsWe found that PM2.5 exposure between weeks 11-32 of gestation (days 80-226) was significantly associated with children's increased SBP. Similarly, PM2.5 exposure between weeks 9-25 of gestation (days 63-176) was significantly associated with increased DBP. To place this into context, a constant 10 ?g/m3 increase in PM2.5 sustained throughout this critical window would predict a cumulative increase of 2.6 mmHg (CI: 0.5, 4.6) in SBP and 0.88 mmHg (CI: 0.1, 1.6) in DBP at ages 4-6 years. In a stratified analysis by sex, this association persisted in boys but not in girls.ConclusionsSecond and third trimester PM2.5 exposure may increase children's BP in early life. Further work investigating PM2.5 exposure with BP trajectories later in childhood will be important to understanding cardiorenal trajectories that may predict adult disease. Our results underscore the importance of reducing air pollution exposure among susceptible populations, including pregnant women.

Dataset Information

Effects of Prenatal PM₁₀ Exposure on Fetal Cardiovascular Malformations in Fuzhou, China: A Retrospective Case-Control Study.

Background

Objectives

Methods

Results

Conclusions

Publications

Effects of Prenatal PM<sub>10</sub> Exposure on Fetal Cardiovascular Malformations in Fuzhou, China: A Retrospective Case-Control Study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Effects of Prenatal PM10 Exposure on Fetal Cardiovascular Malformations in Fuzhou, China: A Retrospective Case-Control Study.

Background

Objectives

Methods

Results

Conclusions

Publications

Effects of Prenatal PM<sub>10</sub> Exposure on Fetal Cardiovascular Malformations in Fuzhou, China: A Retrospective Case-Control Study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Effects of Prenatal PM₁₀ Exposure on Fetal Cardiovascular Malformations in Fuzhou, China: A Retrospective Case-Control Study.