Ontology highlight
ABSTRACT:
SUBMITTER: Jung EM
PROVIDER: S-EPMC5726525 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Jung Eui-Man EM Moffat Jeffrey Jay JJ Liu Jinxu J Dravid Shashank Manohar SM Gurumurthy Channabasavaiah Basavaraju CB Kim Woo-Yang WY
Nature neuroscience 20171106 12
Haploinsufficiency of the AT-rich interactive domain 1B (ARID1B) gene causes autism spectrum disorder and intellectual disability; however, the neurobiological basis for this is unknown. Here we generated Arid1b-knockout mice and examined heterozygotes to model human patients. Arid1b-heterozygous mice showed a decreased number of cortical GABAergic interneurons and reduced proliferation of interneuron progenitors in the ganglionic eminence. Arid1b haploinsufficiency also led to an imbalance betw ...[more]