Ontology highlight
ABSTRACT:
SUBMITTER: Malik A
PROVIDER: S-EPMC5726643 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Malik Amna A Adland Emily E Laker Leana L Kløverpris Henrik H Fardoos Rabiah R Roider Julia J Severinsen Mai C MC Chen Fabian F Riddell Lynn L Edwards Anne A Buus Søren S Jooste Pieter P Matthews Philippa C PC Goulder Philip J R PJR
PloS one 20171212 12
More than 90% of children in Africa are infected with cytomegalovirus (CMV) by the age of 12 months. However, the high-frequency, immunodominant CD8+ T-cell responses that control CMV infection have not been well studied in African populations. We therefore sought to define the immunodominant CMV-specific CD8+ T-cell responses within sub-Saharan African study subjects. Among 257 subjects, we determined the CD8+ T-cell responses to overlapping peptides spanning three of the most immunogenic CMV p ...[more]