Ontology highlight
ABSTRACT:
SUBMITTER: Naegeli KM
PROVIDER: S-EPMC5726793 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Developmental cell 20171101 4
Invasive cells use small invadopodia to breach basement membrane (BM), a dense matrix that encases tissues. Following the breach, a large protrusion forms to clear a path for tissue entry by poorly understood mechanisms. Using RNAi screening for defects in Caenorhabditis elegans anchor cell (AC) invasion, we found that UNC-6(netrin)/UNC-40(DCC) signaling at the BM breach site directs exocytosis of lysosomes using the exocyst and SNARE SNAP-29 to form a large protrusion that invades vulval tissue ...[more]