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Fluctuations in instantaneous frequency predict alpha amplitude during visual perception.

ABSTRACT: Rhythmic neural activity in the alpha band (8-13?Hz) is thought to have an important role in the selective processing of visual information. Typically, modulations in alpha amplitude and instantaneous frequency are thought to reflect independent mechanisms impacting dissociable aspects of visual information processing. However, in complex systems with interacting oscillators such as the brain, amplitude and frequency are mathematically dependent. Here, we record electroencephalography in human subjects and show that both alpha amplitude and instantaneous frequency predict behavioral performance in the same visual discrimination task. Consistent with a model of coupled oscillators, we show that fluctuations in instantaneous frequency predict alpha amplitude on a single trial basis, empirically demonstrating that these metrics are not independent. This interdependence suggests that changes in amplitude and instantaneous frequency reflect a common change in the excitatory and inhibitory neural activity that regulates alpha oscillations and visual information processing.

SUBMITTER: Nelli S

PROVIDER: S-EPMC5727061 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Fluctuations in instantaneous frequency predict alpha amplitude during visual perception.

Nelli Stephanie S Itthipuripat Sirawaj S Srinivasan Ramesh R Serences John T JT

Nature communications 20171212 1

Rhythmic neural activity in the alpha band (8-13 Hz) is thought to have an important role in the selective processing of visual information. Typically, modulations in alpha amplitude and instantaneous frequency are thought to reflect independent mechanisms impacting dissociable aspects of visual information processing. However, in complex systems with interacting oscillators such as the brain, amplitude and frequency are mathematically dependent. Here, we record electroencephalography in human s ...[more]

PMID: 29234068

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Project description:Tinnitus, a phantom ringing, buzzing, or hissing sensation with potentially debilitating consequences, is thought to arise from aberrant spontaneous neural activity at one or more sites within the central nervous system; however, the location and specific features of these oscillations are poorly understood with respect to specific tinnitus features. Recent resting-state functional magnetic resonance imaging (fMRI) studies suggest that aberrant fluctuations in spontaneous low-frequency oscillations (LFO) of the blood oxygen level-dependent (BOLD) signal may be an important factor in chronic tinnitus; however, the role that frequency-specific components of LFO play in subjective tinnitus remains unclear. A total of 39 chronic tinnitus patients and 41 well-matched healthy controls participated in the resting-state fMRI scans. The LFO amplitudes were investigated using the amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) in two different frequency bands (slow-4: 0.027-0.073 Hz and slow-5: 0.01-0.027 Hz). We observed significant differences between tinnitus patients and normal controls in ALFF/fALFF in the two bands (slow-4 and slow-5) in several brain regions including the superior frontal gyrus (SFG), inferior frontal gyrus, middle temporal gyrus, angular gyrus, supramarginal gyrus, and middle occipital gyrus. Across the entire subject pool, significant differences in ALFF/fALFF between the two bands were found in the midbrain, basal ganglia, hippocampus and cerebellum (Slow 4 > Slow 5), and in the middle frontal gyrus, supramarginal gyrus, posterior cingulate cortex, and precuneus (Slow 5 > Slow 4). We also observed significant interaction between frequency bands and patient groups in the orbitofrontal gyrus. Furthermore, tinnitus distress was positively correlated with the magnitude of ALFF in right SFG and the magnitude of fALFF slow-4 band in left SFG, whereas tinnitus duration was positively correlated with the magnitude of ALFF in right SFG and the magnitude of fALFF slow-5 band in left SFG. Resting-state fMRI provides an unbiased method for identifying aberrant spontaneous LFO occurring throughout the central nervous system. Chronic tinnitus patients have widespread abnormalities in ALFF and fALFF slow-4 and slow-5 band which are correlated with tinnitus distress and duration. These results provide new insights on the neuropathophysiology of chronic tinnitus; therapies capable of reversing these aberrant patterns may reduce tinnitus distress.

Project description:While the resting-state individual alpha frequency (IAF) is related to the cognitive performance and temporal resolution of visual perception, it remains unclear how it affects the neural correlates of visual perception and reaction processes. This study aimed to unravel the relation between IAF, visual perception, and visuomotor reaction time. One hundred forty-eight (148) participants (28 non-athletes, 39 table tennis players, and 81 badminton players) investigated in three previous studies were considered. During a visuomotor reaction task, the visuomotor reaction time (VMRT) and EMG onset were determined. In addition, a 64-channel EEG system identified the N2, N2-r, and BA6 negativity potentials representing the visual and motor processes related to visuomotor reactions. Resting-state individual alpha frequency (IAF) in visual and motor regions was compared based on sport experience (athletes vs. non-athletes), discipline (badminton vs. table tennis), and reaction performance (fast vs. medium vs. slow reaction time). Further, the differences in the IAF were determined in relation to the speed of neural visual (high vs. medium vs. low N2/N2-r latency) and motor (high vs. medium vs. low BA6 negativity latency). Group comparisons did not reveal any difference in the IAF between athletes and non-athletes (p = 0.352, η p 2 = 0.02) or badminton and table tennis players (p = 0.221, η p 2 = 0.02). Similarly, classification based on the behavioral or neural performance indicators did not reveal any effects on the IAF (p ≥ 0.158, η p 2 ≤ 0.027). IAF was not correlated to any of the behavioral or neural parameters (r ≤ 0.10, p ≥ 0.221). In contrast to behavioral results on cognitive performance and visual temporal resolution, the resting state IAF seemed unrelated to the visual perception and visuomotor reaction speed in simple reaction tasks. Considering the previous results on the correlations between the IAF, cognitive abilities, and temporal sampling of visual information, the results suggest that a higher IAF may facilitate the amount and frequency but not the speed of information transfer.

Dataset Information

Fluctuations in instantaneous frequency predict alpha amplitude during visual perception.

Publications

Fluctuations in instantaneous frequency predict alpha amplitude during visual perception.

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