Ontology highlight
ABSTRACT:
SUBMITTER: Lavigne MD
PROVIDER: S-EPMC5727188 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Lavigne Matthieu D MD Konstantopoulos Dimitris D Ntakou-Zamplara Katerina Z KZ Liakos Anastasios A Fousteri Maria M
Nature communications 20171212 1
Complex molecular responses preserve gene expression accuracy and genome integrity in the face of environmental perturbations. Here we report that, in response to UV irradiation, RNA polymerase II (RNAPII) molecules are dynamically and synchronously released from promoter-proximal regions into elongation to promote uniform and accelerated surveillance of the whole transcribed genome. The maximised influx of de novo released RNAPII correlates with increased damage-sensing, as confirmed by RNAPII ...[more]