Unknown

Dataset Information

0

Multipulse sodium magnetic resonance imaging for multicompartment quantification: Proof-of-concept.


ABSTRACT: We present a feasibility study of sodium quantification in a multicompartment model of the brain using sodium (23Na) magnetic resonance imaging. The proposed method is based on a multipulse sequence acquisition and simulation at 7 T, which allows to differentiate the 23Na signals emanating from three compartments in human brain in vivo: intracellular (compartment 1), extracellular (compartment 2), and cerebrospinal fluid (compartment 3). The intracellular sodium concentration C 1 and the volume fractions α 1, α 2, and α 3 of all respective three brain compartments can be estimated. Simulations of the sodium spin 3/2 dynamics during a 15-pulse sequence were used to optimize the acquisition sequence by minimizing the correlation between the signal evolutions from the three compartments. The method was first tested on a three-compartment phantom as proof-of-concept. Average values of the 23Na quantifications in four healthy volunteer brains were α 1 = 0.54 ± 0.01, α 2 = 0.23 ± 0.01, α 3 = 1.03 ± 0.01, and C 1 = 23 ± 3 mM, which are comparable to the expected physiological values [Formula: see text] ∼ 0.6, [Formula: see text] ∼ 0.2, [Formula: see text] ∼ 1, and [Formula: see text] ∼ 10-30 mM. The proposed method may allow a quantitative assessment of the metabolic role of sodium ions in cellular processes and their malfunctions in brain in vivo.

SUBMITTER: Gilles A 

PROVIDER: S-EPMC5727256 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Multipulse sodium magnetic resonance imaging for multicompartment quantification: Proof-of-concept.

Gilles Alina A   Nagel Armin M AM   Madelin Guillaume G  

Scientific reports 20171212 1


We present a feasibility study of sodium quantification in a multicompartment model of the brain using sodium (<sup>23</sup>Na) magnetic resonance imaging. The proposed method is based on a multipulse sequence acquisition and simulation at 7 T, which allows to differentiate the <sup>23</sup>Na signals emanating from three compartments in human brain in vivo: intracellular (compartment 1), extracellular (compartment 2), and cerebrospinal fluid (compartment 3). The intracellular sodium concentrati  ...[more]

Similar Datasets

| S-EPMC9673621 | biostudies-literature
| S-EPMC10951905 | biostudies-literature
| S-EPMC9204632 | biostudies-literature
| S-EPMC6295241 | biostudies-literature
| S-EPMC11647431 | biostudies-literature
| S-EPMC10324328 | biostudies-literature
| S-EPMC8035170 | biostudies-literature
| S-EPMC6701782 | biostudies-literature
| S-EPMC5993783 | biostudies-literature
| S-EPMC11360801 | biostudies-literature