Ontology highlight
ABSTRACT:
SUBMITTER: Flachsbart F
PROVIDER: S-EPMC5727304 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Nature communications 20171212 1
FOXO3 is consistently annotated as a human longevity gene. However, functional variants and underlying mechanisms for the association remain unknown. Here, we perform resequencing of the FOXO3 locus and single-nucleotide variant (SNV) genotyping in three European populations. We find two FOXO3 SNVs, rs12206094 and rs4946935, to be most significantly associated with longevity and further characterize them functionally. We experimentally validate the in silico predicted allele-dependent binding of ...[more]