Ontology highlight
ABSTRACT:
SUBMITTER: Kulkeaw K
PROVIDER: S-EPMC5728333 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Kulkeaw Kasem K Inoue Tomoko T Iino Tadafumi T Tani Kenzaburo K Akashi Koichi K Speck Nancy A NA Nakanishi Yoichi Y Sugiyama Daisuke D
Blood advances 20170831 20
Mechanisms underlying differentiation of embryonic hematopoietic stem/progenitor cells (HSPCs) remain unclear. In mouse, intra-aortic clusters (IACs) form in the aorta-gonad-mesonephros region and acquire HSPC potential after 9.5 days postcoitum (dpc). In this study we demonstrate that Twist1 is highly expressed in c-Kit<sup>+</sup>CD31<sup>+</sup>CD34<sup>+</sup> IACs, which are equivalent to embryonic HSPCs, compared with adult HSPCs. Progenitor activities of colony-forming unit (CFU) of granu ...[more]