Ontology highlight
ABSTRACT:
SUBMITTER: Gatti DM
PROVIDER: S-EPMC5729066 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Gatti D M DM Weber S N SN Goodwin N C NC Lammert F F Churchill G A GA
The pharmacogenomics journal 20170613 2
Hematotoxicity is a life-threatening side effect of many chemotherapy regimens. Although clinical factors influence patient responses, genetic factors may also play an important role. We sought to identify genomic loci that influence chemotherapy-induced hematotoxicity by dosing Diversity Outbred mice with one of three chemotherapy drugs; doxorubicin, cyclophosphamide or docetaxel. We observed that each drug had a distinct effect on both the changes in blood cell subpopulations and the underlyin ...[more]