Oxytocin Modulates Attention Switching Between Interoceptive Signals and External Social Cues.

ABSTRACT: Emotional experience involves an integrated interplay between processing of external emotional cues and interoceptive feedback, and this is impaired in a number of emotional disorders. The neuropeptide oxytocin (OT) enhances the salience of external social cues but its influence on interoception is unknown. The present pharmaco-fMRI study therefore investigated whether OT enhances interoceptive awareness and if it influences the interplay between interoceptive and salience processing. In a randomized, double-blind, between-subject, design study 83 subjects received either intranasal OT or placebo. In Experiment 1, subjects performed a heartbeat detection task alone, while in Experiment 2 they did so while viewing both neutral and emotional face stimuli. Interoceptive accuracy and neural re

SUBMITTER: Yao S 

PROVIDER: S-EPMC5729568 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature