Ontology highlight
ABSTRACT:
SUBMITTER: Puppala M
PROVIDER: S-EPMC5729742 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Puppala Manohar M Narayanapillai Sreekanth C SC Leitzman Pablo P Sun Haifeng H Upadhyaya Pramod P O'Sullivan M Gerard MG Hecht Stephen S SS Xing Chengguo C
Journal of medicinal chemistry 20170913 18
(+)-Dihydromethysticin was recently identified as a promising lung cancer chemopreventive agent, while (+)-dihydrokavain was completely ineffective. A pilot in vivo structure-activity relationship (SAR) was explored, evaluating the efficacy of its analogs in blocking 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced short-term O<sup>6</sup>-methylguanine and long-term adenoma formation in the lung tissues in A/J mice. Both results revealed cohesive SARs, demonstrating that the methylenediox ...[more]