Ontology highlight
ABSTRACT:
SUBMITTER: Guan BJ
PROVIDER: S-EPMC5730339 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Guan Bo-Jhih BJ van Hoef Vincent V Jobava Raul R Elroy-Stein Orna O Valasek Leos S LS Cargnello Marie M Gao Xing-Huang XH Krokowski Dawid D Merrick William C WC Kimball Scot R SR Komar Anton A AA Koromilas Antonis E AE Wynshaw-Boris Anthony A Topisirovic Ivan I Larsson Ola O Hatzoglou Maria M
Molecular cell 20171201 5
The integrated stress response (ISR) is a homeostatic mechanism induced by endoplasmic reticulum (ER) stress. In acute/transient ER stress, decreased global protein synthesis and increased uORF mRNA translation are followed by normalization of protein synthesis. Here, we report a dramatically different response during chronic ER stress. This chronic ISR program is characterized by persistently elevated uORF mRNA translation and concurrent gene expression reprogramming, which permits simultaneous ...[more]