Ontology highlight
ABSTRACT:
SUBMITTER: Kannan A
PROVIDER: S-EPMC5730406 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
European journal of immunology 20150610 8
Itk(-/-) mice exhibit defects in the activation, development, and function of CD4(+) and CD8(+) T cells and iNKT cells. These and other defects in these mice make it difficult to uncouple the developmental versus functional requirement of Itk signaling. Here, we report an allele-sensitive mutant of Itk (Itkas) whose catalytic activity can be selectively inhibited by analogs of the PP1 kinase inhibitor. We show that Itkas behaves like WT Itk in the absence of the inhibitor and can rescue the deve ...[more]