Ontology highlight
ABSTRACT:
SUBMITTER: Yang JH
PROVIDER: S-EPMC5730482 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Yang Jason H JH Bhargava Prerna P McCloskey Douglas D Mao Ning N Palsson Bernhard O BO Collins James J JJ
Cell host & microbe 20171130 6
Bactericidal antibiotics alter microbial metabolism as part of their lethality and can damage mitochondria in mammalian cells. In addition, antibiotic susceptibility is sensitive to extracellular metabolites, but it remains unknown whether metabolites present at an infection site can affect either treatment efficacy or immune function. Here, we quantify local metabolic changes in the host microenvironment following antibiotic treatment for a peritoneal Escherichia coli infection. Antibiotic trea ...[more]