Unknown

Dataset Information

0

Correlation of Handheld Reflectance Confocal Microscopy With Radial Video Mosaicing for Margin Mapping of Lentigo Maligna and Lentigo Maligna Melanoma.


ABSTRACT: Importance:The management of lentigo maligna (LM) and LM melanoma (LMM) is challenging because of extensive subclinical spread and its occurrence on cosmetically sensitive areas. Reflectance confocal microscopy (RCM) improves diagnostic accuracy for LM and LMM and can be used to delineate their margins. Objectives:To evaluate whether handheld RCM with radial video mosaicing (HRCM-RV) offers accurate presurgical assessment of LM and LMM margins. Design, Setting, and Participants:This prospective study included consecutive patients with biopsy-proven LM and LMM located on the head and neck area who sought consultation for surgical management from March 1, 2016, through March 31, 2017, at the Dermatology Service of the Memorial Sloan Kettering Cancer Center. Thirty-two patients underwent imaging using HRCM-RV, and 22 patients with 23 LM or LMM lesions underwent staged surgery and contributed to the analysis. Main Outcomes and Measures:Clinical lesion size and area, LM and LMM area based on HRCM-RV findings, surgical defect area estimated by HRCM-RV, and observed surgical defect area. In addition, the margins measured in millimeters estimated for tumor clearance in each quadrant based on HRCM-RV findings were calculated and compared with the surgical margins. Results:Among the 22 patients (12 men and 10 women; mean [SD] age, 69.0 [8.6] years [range, 46-83 years]) with 23 lesions included in the final analysis, the mean (SD) surgical defect area estimated with HRCM-RV was 6.34 (4.02) cm2 and the mean (SD) area of surgical excision with clear margins was 7.74 (5.28) cm2. Overall, controlling for patient age and previous surgery, surgical margins were a mean of 0.76 mm (95% CI, 0.67-0.84 mm; P?

SUBMITTER: Yelamos O 

PROVIDER: S-EPMC5730495 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Correlation of Handheld Reflectance Confocal Microscopy With Radial Video Mosaicing for Margin Mapping of Lentigo Maligna and Lentigo Maligna Melanoma.

Yélamos Oriol O   Cordova Miguel M   Blank Nina N   Kose Kivanc K   Dusza Stephen W SW   Lee Erica E   Rajadhyaksha Milind M   Nehal Kishwer S KS   Rossi Anthony M AM  

JAMA dermatology 20171201 12


<h4>Importance</h4>The management of lentigo maligna (LM) and LM melanoma (LMM) is challenging because of extensive subclinical spread and its occurrence on cosmetically sensitive areas. Reflectance confocal microscopy (RCM) improves diagnostic accuracy for LM and LMM and can be used to delineate their margins.<h4>Objectives</h4>To evaluate whether handheld RCM with radial video mosaicing (HRCM-RV) offers accurate presurgical assessment of LM and LMM margins.<h4>Design, setting, and participants  ...[more]

Similar Datasets

| S-EPMC5569302 | biostudies-literature
| S-EPMC7592341 | biostudies-literature
| S-EPMC5710297 | biostudies-literature
| S-EPMC7362499 | biostudies-literature
| S-EPMC6534461 | biostudies-literature
2021-11-26 | GSE174395 | GEO
| S-EPMC7554192 | biostudies-literature
| S-EPMC7671473 | biostudies-literature
| S-EPMC8743714 | biostudies-literature
| S-EPMC6076978 | biostudies-literature