Calneuron 1 Increased Ca²⁺ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma.

ABSTRACT: Aldosterone production is initiated by angiotensin II stimulation and activation of intracellular Ca²⁺ signaling. In aldosterone-producing adenoma (APA) cells, the activation of intracellular Ca²⁺ signaling is independent of the renin-angiotensin-aldosterone systems. The purpose of our study was to clarify molecular mechanisms of aldosterone production related to Ca²⁺ signaling. Transcriptome analysis revealed that the CALN1 gene encoding calneuron 1 had the strongest correlation with CYP11B2 (aldosterone synthase) among genes encoding Ca²⁺-binding proteins in APA. CALN1 modulation and synthetic or fluorescent compounds were used for functional studies in human adrenocortical carcinoma (HAC15) cells. CALN1 expression w

SUBMITTER: Kobuke K 

PROVIDER: S-EPMC5730498 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature