Ontology highlight
ABSTRACT:
SUBMITTER: Skrott Z
PROVIDER: S-EPMC5730499 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Skrott Zdenek Z Mistrik Martin M Andersen Klaus Kaae KK Friis Søren S Majera Dusana D Gursky Jan J Ozdian Tomas T Bartkova Jirina J Turi Zsofia Z Moudry Pavel P Kraus Marianne M Michalova Martina M Vaclavkova Jana J Dzubak Petr P Vrobel Ivo I Pouckova Pavla P Sedlacek Jindrich J Miklovicova Andrea A Kutt Anne A Li Jing J Mattova Jana J Driessen Christoph C Dou Q Ping QP Olsen Jørgen J Hajduch Marian M Cvek Boris B Deshaies Raymond J RJ Bartek Jiri J
Nature 20171206 7684
Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need for improved cancer treatment is drug repurposing. Here we highlight the potential for repurposing disulfiram (also known by the trade name Antabuse), an old alcohol-aversion drug that has been shown to be effective against diverse cancer types in preclinical studies. Our nationwide epidemiological study reveals that patients who continuou ...[more]