Ontology highlight
ABSTRACT:
SUBMITTER: Ngambenjawong C
PROVIDER: S-EPMC5730504 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Ngambenjawong Chayanon C Gustafson Heather H HH Sylvestre Meilyn M Pun Suzie H SH
Chembiochem : a European journal of chemical biology 20171107 24
Peptides are a growing class of macromolecules used in pharmaceutics. The path toward the clinical use of candidate peptides involves sequence optimization and cyclization for stability and affinity. For internalized peptides, tagging is also often required for intracellular trafficking studies, although fluorophore conjugation has an impact on peptide binding, permeability, and localization. Herein, a strategy based on cysteine arylation with tetrafluoroterephthalonitrile (4F-2CN), which simult ...[more]