Ontology highlight
ABSTRACT:
SUBMITTER: Aze A
PROVIDER: S-EPMC5730577 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Aze Antoine A Fragkos Michalis M Bocquet Stéphane S Cau Julien J Méchali Marcel M
Nature communications 20171214 1
Upon fertilisation, the sperm pronucleus acquires the competence to replicate the genome through a cascade of events that link chromatin remodelling to nuclear envelope formation. The factors involved have been partially identified and are poorly characterised. Here, using Xenopus laevis egg extracts we show that RNAs are required for proper nuclear envelope assembly following sperm DNA decondensation. Although chromatin remodelling and pre-replication complex formation occur normally, RNA-deple ...[more]