Ontology highlight
ABSTRACT:
SUBMITTER: Brehs M
PROVIDER: S-EPMC5730604 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Brehs Manuel M Pötgens André J G AJG Steitz Julia J Thewes Karine K Schwarz Janett J Conibear Anne C AC Bartneck Matthias M Tacke Frank F Becker Christian F W CFW
Scientific reports 20171214 1
Immuno-oncology approaches mainly utilize monoclonal antibodies or protein-based scaffolds that bind with high affinity to cancer cells and can generate an immune response. Peptides can also bind with high affinity to cancer cells and are intermediate in size between antibodies and small molecules. They are also synthetically accessible and therefore easily modified to optimize their stability, binding affinity and selectivity. Here we describe the design of immune system engagers (ISErs), a nov ...[more]