Effect of Metabolic Syndrome on Late-Life Depression: Associations with Disease Severity and Treatment Resistance.

ABSTRACT:

Background/objectives

Metabolic syndrome (MetS) is the co-occurrence of obesity and metabolic derangements. Prior research implicates MetS in prolongation of the course of depression in older adults, but its effect on antidepressant response is unknown in this population. The objective was to determine whether MetS and related metabolic dyscrasias are associated with decreased rate of remission from depression in older adults treated pharmacologically for depression.

Design

Secondary analysis of a randomized controlled trial.

Setting

Three academic medical centers in North America.

Participants

Adults aged 60 and older (mean age 69.1) with major depressive disorder (MDD) (N = 435).

Intervention

Open-label, protocolized treatment with extended-release ven

SUBMITTER: Mulvahill JS 

PROVIDER: S-EPMC5730877 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature