Ontology highlight
ABSTRACT:
SUBMITTER: Marra A
PROVIDER: S-EPMC5730951 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Marra Antonio A Scognamiglio Giosuè G Peluso Ilaria I Botti Gerardo G Fusciello Celeste C Filippelli Amelia A Ascierto Paolo A PA Pepe Stefano S Sabbatino Francesco F
The open AIDS journal 20171114
<h4>Introduction</h4>Immunotherapy with immune checkpoint inhibitors increases the overall survival of patients with metastatic melanoma regardless of their oncogene addicted mutations. However, no data is available from clinical trials of effective therapies in subgroups of melanoma patients that carry chronic infective diseases such as HIV. Evidences suggest a key role of the immune checkpoint molecules as a mechanism of immune escape not only from melanoma but also from HIV host immune respon ...[more]