Ontology highlight
ABSTRACT:
SUBMITTER: Cephus JY
PROVIDER: S-EPMC5731254 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Cephus Jacqueline-Yvonne JY Stier Matthew T MT Fuseini Hubaida H Yung Jeffrey A JA Toki Shinji S Bloodworth Melissa H MH Zhou Weisong W Goleniewska Kasia K Zhang Jian J Garon Sarah L SL Hamilton Robert G RG Poloshukin Vasiliy V VV Boyd Kelli L KL Peebles R Stokes RS Newcomb Dawn C DC
Cell reports 20171101 9
Sex hormones regulate many autoimmune and inflammatory diseases, including asthma. As adults, asthma prevalence is 2-fold greater in women compared to men. The number of group 2 innate lymphoid cells (ILC2) is increased in patients with asthma, and we investigate how testosterone attenuates ILC2 function. In patients with moderate to severe asthma, we determine that women have an increased number of circulating ILC2 compared to men. ILC2 from adult female mice have increased IL-2-mediated ILC2 p ...[more]