Ontology highlight
ABSTRACT:
SUBMITTER: Haspel N
PROVIDER: S-EPMC5731496 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
BMC bioinformatics 20171206 Suppl 15
<h4>Background</h4>Understanding protein structure and dynamics is essential for understanding their function. This is a challenging task due to the high complexity of the conformational landscapes of proteins and their rugged energy levels. In particular, it is important to detect highly populated regions which could correspond to intermediate structures or local minima.<h4>Results</h4>We present a hierarchical clustering and algebraic topology based method that detects regions of interest in p ...[more]