Ontology highlight
ABSTRACT:
SUBMITTER: Pera M
PROVIDER: S-EPMC5731665 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Pera Marta M Larrea Delfina D Guardia-Laguarta Cristina C Montesinos Jorge J Velasco Kevin R KR Agrawal Rishi R RR Xu Yimeng Y Chan Robin B RB Di Paolo Gilbert G Mehler Mark F MF Perumal Geoffrey S GS Macaluso Frank P FP Freyberg Zachary Z ZZ Acin-Perez Rebeca R Enriquez Jose Antonio JA Schon Eric A EA Area-Gomez Estela E
The EMBO journal 20171010 22
In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β-secretase to generate a 99-aa C-terminal fragment (C99) that is then cleaved by γ-secretase to generate the β-amyloid (Aβ) found in senile plaques. In previous reports, we and others have shown that γ-secretase activity is enriched in mitochondria-associated endoplasmic reticulum (ER) membranes (MAM) and that ER-mitochondrial connectivity and MAM function are upregulated in AD ...[more]