Dataset Information

Tumor image-derived texture features are associated with CD3 T-cell infiltration status in glioblastoma.

ABSTRACT: This study analyzed magnetic resonance imaging (MRI) scans of Glioblastoma (GB) patients to develop an imaging-derived predictive model for assessing the extent of intratumoral CD3 T-cell infiltration. Pre-surgical T1-weighted post-contrast and T2-weighted Fluid-Attenuated-Inversion-Recovery (FLAIR) MRI scans, with corresponding mRNA expression of CD3D/E/G were obtained through The Cancer Genome Atlas (TCGA) for 79 GB patients. The tumor region was contoured and 86 image-derived features were extracted across the T1-post contrast and FLAIR images. Six imaging features-kurtosis, contrast, small zone size emphasis, low gray level zone size emphasis, high gray level zone size emphasis, small zone high gray level emphasis-were found associated with CD3 activity and used to build a predictive model for CD3 infiltration in an independent data set of 69 GB patients (using a 50-50 split for training and testing). For the training set, the image-based prediction model for CD3 infiltration achieved accuracy of 97.1% and area under the curve (AUC) of 0.993. For the test set, the model achieved accuracy of 76.5% and AUC of 0.847. This suggests a relationship between image-derived textural features and CD3 T-cell infiltration enabling the non-invasive inference of intratumoral CD3 T-cell infiltration in GB patients, with potential value for the radiological assessment of response to immune therapeutics.

SUBMITTER: Narang S

PROVIDER: S-EPMC5731870 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Tumor image-derived texture features are associated with CD3 T-cell infiltration status in glioblastoma.

Narang Shivali S Kim Donnie D Aithala Sathvik S Heimberger Amy B AB Ahmed Salmaan S Rao Dinesh D Rao Ganesh G Rao Arvind A

Oncotarget 20170905 60

This study analyzed magnetic resonance imaging (MRI) scans of Glioblastoma (GB) patients to develop an imaging-derived predictive model for assessing the extent of intratumoral CD3 T-cell infiltration. Pre-surgical T1-weighted post-contrast and T2-weighted Fluid-Attenuated-Inversion-Recovery (FLAIR) MRI scans, with corresponding mRNA expression of CD3D/E/G were obtained through The Cancer Genome Atlas (TCGA) for 79 GB patients. The tumor region was contoured and 86 image-derived features were ex ...[more]

PMID: 29254160

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Dataset Information

Tumor image-derived texture features are associated with CD3 T-cell infiltration status in glioblastoma.

Publications

Tumor image-derived texture features are associated with CD3 T-cell infiltration status in glioblastoma.

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