NDRG4 promotes myogenesis via Akt/CREB activation.
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ABSTRACT:
SUBMITTER: Zhu M
PROVIDER: S-EPMC5731909 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
NDRG4 promotes myogenesis via Akt/CREB activation.
Zhu Mingfei M Zheng Rong R Guo Yiwen Y Zhang Yunxia Y Zuo Bo B
Oncotarget 20171006 60
N-Myc downstream-regulated gene 4 (<i>NDRG4</i>) plays an important role in biological processes and pathogenesis, but its function in muscle development is unclear. In this study, we investigated the function of the <i>NDRG4</i> gene in the regulation of myogenic differentiation. NDRG4 expression is upregulated during muscle regeneration and C2C12 myoblast differentiation. Gain and loss of function studies revealed that NDRG4 dramatically promotes expression of myogenic differentiation factor ( ...[more]
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