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Genetic polymorphisms in the ALDH2 gene and the risk of ischemic stroke in a Chinese han population.

ABSTRACT: Previous studies have shown that aldehyde dehydrogenase 2 (ALDH2) plays a role in ischemic stroke progression. In recent years, the activation of the ALDH2 pathway have been reported serving as a useful index in the identification of stroke-prone participants, and the ALDH2 pathway may be a potential target for the therapeutic intervention in ischemic stroke.We evaluated six tagging single-nucleotide polymorphisms (SNPs) of the ALDH2 gene in a case-control study from Hainan of China (488 cases, 503 controls). We used SPSS version 17.0 statistical software, Excel software and other analysis software to explore associations between SNPs and the risk of ischemic stroke various genetic models (additive, dominant, and recessive).Through statistical analysis, we found that ALDH2 rs886205 [odds ratio (OR) = 6.39; 95% confidence interval (CI) = 1.19-34.38; p = 0.03] and rs7296651 (OR = 9.29; 95% CI = 1.37-63.21; p = 0.02) were associated with increased risk of ischemic stroke in recessive model analysis. In addition, we established that the "AA" genotype (OR = 5.99; 95% CI = 1.11-32.23; p = 0.037) for rs886205 and the "AA" genotype (OR = 8.93; 95% CI = 1.31-60.78; p = 0.025) for rs7296651 were associated with increased ischemic stroke risk.Our results provide evidence that variants of ALDH2 gene polymorphisms influence the risk of developing ischemic stroke in Han Chinese population.

SUBMITTER: Sun S

PROVIDER: S-EPMC5731925 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Genetic polymorphisms in the <i>ALDH2</i> gene and the risk of ischemic stroke in a Chinese han population.

Sun Shuaiqi S He Jun J Zhang Yao Y Xiao Rongjun R Yan Mengdan M Ren Yulin Y Zhu Yuanyuan Y Jin Tianbo T Xia Ying Y

Oncotarget 20171010 60

<h4>Background</h4>Previous studies have shown that aldehyde dehydrogenase 2 (<i>ALDH2</i>) plays a role in ischemic stroke progression. In recent years, the activation of the <i>ALDH2</i> pathway have been reported serving as a useful index in the identification of stroke-prone participants, and the <i>ALDH2</i> pathway may be a potential target for the therapeutic intervention in ischemic stroke.<h4>Materials and methods</h4>We evaluated six tagging single-nucleotide polymorphisms (SNPs) of th ...[more]

PMID: 29254215

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Project description:Numerous genetic polymorphisms and clinical laboratory parameters are associated with ischemic stroke (IS). However, the results of such studies have frequently been inconsistent. The aim of the present study was to evaluate associations between clinical laboratory parameters with genetic polymorphisms that influence the risk of IS in a Chinese Han population. Clinical laboratory parameters were measured by an automatic biochemical analyzer. Genotype and allele frequencies of the polymorphisms angiotensin-converting enzyme (ACE) D/I, methylene tetrahydrofolate reductase (MTHFR) C677T and β-fibrinogen (β-Fg) A/G, 455/148T/C were characterized by restriction fragment length polymorphism-PCR. Furthermore, the gene polymorphisms plasminogen activator inhibitor (PAI)-1-4G/5G and apolipoprotein E (ApoE) ε2,3,4 were characterized by allele-specific PCR. The associations of genotype and allele frequencies of the six risk genes in different groups with clinical laboratory parameters were analyzed by chi-square tests. The distribution maps of the polymorphisms of the six genes and clinical laboratory parameters were compared between a control group of 336 healthy individuals and 762 patients with IS. Certain laboratory parameters were associated with ACE I/D, β-Fg-455 A/G and PAI-1 4G/5G. The D allele of ACE I/D was associated with high levels of total cholesterol and low-density lipoprotein cholesterol (LDL-C). Furthermore, high levels of fasting blood glucose, triglyceride and LDL-C were risk factors for IS. There were significant differences in the genotype frequencies of ACE I/D, β-Fg-455 A/G and β-Fg-148 T/C between the IS and the control group. In conclusion, clinical laboratory parameters were associated with the risk of polymorphisms of IS-related genes. The present results support the determination of a range of control values of clinical laboratory parameters for common genotypes in patients with diabetes and hyperlipidemia as a strategy for the early prevention of IS.

Dataset Information

Genetic polymorphisms in the ALDH2 gene and the risk of ischemic stroke in a Chinese han population.

Publications

Genetic polymorphisms in the <i>ALDH2</i> gene and the risk of ischemic stroke in a Chinese han population.

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