Ontology highlight
ABSTRACT:
SUBMITTER: Fang JS
PROVIDER: S-EPMC5732288 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Fang Jennifer S JS Coon Brian G BG Gillis Noelle N Chen Zehua Z Qiu Jingyao J Chittenden Thomas W TW Burt Janis M JM Schwartz Martin A MA Hirschi Karen K KK
Nature communications 20171215 1
Establishment of a functional vascular network is rate-limiting in embryonic development, tissue repair and engineering. During blood vessel formation, newly generated endothelial cells rapidly expand into primitive plexi that undergo vascular remodeling into circulatory networks, requiring coordinated growth inhibition and arterial-venous specification. Whether the mechanisms controlling endothelial cell cycle arrest and acquisition of specialized phenotypes are interdependent is unknown. Here ...[more]