Changes in hyaluronan deposition in the rat myenteric plexus after experimentally-induced colitis.
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ABSTRACT:
SUBMITTER: Filpa V
PROVIDER: S-EPMC5732300 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
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Changes in hyaluronan deposition in the rat myenteric plexus after experimentally-induced colitis.
Filpa Viviana V Bistoletti Michela M Caon Ilaria I Moro Elisabetta E Grimaldi Annalisa A Moretto Paola P Baj Andreina A Giron Maria Cecilia MC Karousou Evgenia E Viola Manuela M Crema Francesca F Frigo Gianmario G Passi Alberto A Giaroni Cristina C Vigetti Davide D
Scientific reports 20171215 1
Myenteric plexus alterations hamper gastrointestinal motor function during intestinal inflammation. Hyaluronan (HA), an extracellular matrix glycosaminoglycan involved in inflammatory responses, may play a role in this process. In the colon of control rats, HA-binding protein (HABP), was detected in myenteric neuron soma, perineuronal space and ganglia surfaces. Prominent hyaluronan synthase 2 (HAS2) staining was found in myenteric neuron cytoplasm, suggesting that myenteric neurons produce HA. ...[more]
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