Ontology highlight
ABSTRACT:
SUBMITTER: Celus W
PROVIDER: S-EPMC5732321 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Celus Ward W Di Conza Giusy G Oliveira Ana Isabel AI Ehling Manuel M Costa Bruno M BM Wenes Mathias M Mazzone Massimiliano M
Cell reports 20171201 10
Although it is well established that tumor-associated macrophages take part in each step of cancer progression, less is known about the distinct role of the so-called metastasis-associated macrophages (MAMs) at the metastatic site. Previous studies reported that Caveolin-1 (Cav1) has both tumor-promoting and tumor-suppressive functions. However, the role of Cav1 in bone-marrow-derived cells is unknown. Here, we describe Cav1 as an anti-metastatic regulator in mouse models of lung and breast canc ...[more]