Ontology highlight
ABSTRACT:
SUBMITTER: Liang X
PROVIDER: S-EPMC5732705 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Liang Xueyan X Yang Yufang Y Huang Zhenguang Z Zhou Jinling J Li Yue'e Y Zhong Xiaobin X
Oncotarget 20170803 61
We investigated the role of HIF-1α in the mitigation of cisplatin-induced nephrotoxicity by <i>Panax notoginseng saponins</i> (PNS) in a rat model. Serum creatinine (Scr), blood urea nitrogen (BUN) and urinary N-acetyl-β-D-glucosaminidase (NAG) levels were all elevated in cisplatin treated rats. PNS reduced Scr, BUN and NAG levels in the presence or absence of the HIF-1α inhibitor 2-methoxyestradiol (2ME2). PNS also reduced the high tubular injury scores, which corresponded to renal tubular dama ...[more]