Dataset Information

A framework for exploring associations between biomedical terms in PubMed.

ABSTRACT: Co-occurrence relationships in PubMed between terms accelerate the recognition of term associations. The lack of manually curated relationships in vocabularies and the rapid increase of biomedical literatures highlight the importance of co-occurrence relationships. Here we proposed a framework to explore term associations based on a standard procedure that comprises multiple tools of text mining and relationship degree calculation methods. The text of PubMed were segmented into sentences by Apache OpenNLP first, and then terms of sentences were recognized by MGREP. After that two terms occurring in a common sentence were identified as a co-occurrence relationship. The relationship degree is then calculated using Normalized MEDLINE Distance (NMD) or relationship-scaled score (RSS) method. The framework was utilized in exploring associations between terms of Gene Ontology (GO) and Disease Ontology (DO) based on co-occurrence relationship. Results show that pairs of terms with more co-occurrence relationships indicate shared more semantic relationships of ontology and genes. The identified association terms based on co-occurrence relationships were applied in constructing a disease association network (DAN). The small giant component confirms with the observation that diseases in the same class have more linkage than diseases in different classes.

SUBMITTER: Yang H

PROVIDER: S-EPMC5732714 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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A framework for exploring associations between biomedical terms in PubMed.

Yang Haixiu H Zhao Lingling L Zhang Ying Y Ju Hong H Wang Dong D Hu Yang Y Zhang Jun J Cheng Liang L

Oncotarget 20171005 61

Co-occurrence relationships in PubMed between terms accelerate the recognition of term associations. The lack of manually curated relationships in vocabularies and the rapid increase of biomedical literatures highlight the importance of co-occurrence relationships. Here we proposed a framework to explore term associations based on a standard procedure that comprises multiple tools of text mining and relationship degree calculation methods. The text of PubMed were segmented into sentences by Apac ...[more]

PMID: 29262548

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Project description:BACKGROUND: With the development of high throughput methods of gene analyses, there is a growing need for mining tools to retrieve relevant articles in PubMed. As PubMed grows, literature searches become more complex and time-consuming. Automated search tools with good precision and recall are necessary. We developed GO2PUB to automatically enrich PubMed queries with gene names, symbols and synonyms annotated by a GO term of interest or one of its descendants. RESULTS: GO2PUB enriches PubMed queries based on selected GO terms and keywords. It processes the result and displays the PMID, title, authors, abstract and bibliographic references of the articles. Gene names, symbols and synonyms that have been generated as extra keywords from the GO terms are also highlighted. GO2PUB is based on a semantic expansion of PubMed queries using the semantic inheritance between terms through the GO graph. Two experts manually assessed the relevance of GO2PUB, GoPubMed and PubMed on three queries about lipid metabolism. Experts' agreement was high (kappa?=?0.88). GO2PUB returned 69% of the relevant articles, GoPubMed: 40% and PubMed: 29%. GO2PUB and GoPubMed have 17% of their results in common, corresponding to 24% of the total number of relevant results. 70% of the articles returned by more than one tool were relevant. 36% of the relevant articles were returned only by GO2PUB, 17% only by GoPubMed and 14% only by PubMed. For determining whether these results can be generalized, we generated twenty queries based on random GO terms with a granularity similar to those of the first three queries and compared the proportions of GO2PUB and GoPubMed results. These were respectively of 77% and 40% for the first queries, and of 70% and 38% for the random queries. The two experts also assessed the relevance of seven of the twenty queries (the three related to lipid metabolism and four related to other domains). Expert agreement was high (0.93 and 0.8). GO2PUB and GoPubMed performances were similar to those of the first queries. CONCLUSIONS: We demonstrated that the use of genes annotated by either GO terms of interest or a descendant of these GO terms yields some relevant articles ignored by other tools. The comparison of GO2PUB, based on semantic expansion, with GoPubMed, based on text mining techniques, showed that both tools are complementary. The analysis of the randomly-generated queries suggests that the results obtained about lipid metabolism can be generalized to other biological processes. GO2PUB is available at http://go2pub.genouest.org.

Dataset Information

A framework for exploring associations between biomedical terms in PubMed.

Publications

A framework for exploring associations between biomedical terms in PubMed.

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