Ontology highlight
ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC5732720 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Zhou Jingkai J Zhao Tiangang T Ma Linfeng L Liang Min M Guo Ying-Jie YJ Zhao Li-Mei LM
Oncotarget 20171009 61
Cucurbitacin B (CuB) is a natural tetracyclic triterpene product and displays antitumor activity across a wide array of cancers. In this study, we explored the anti-pancreatic cancer activity of CuB alone and in combination with SCH772984, an ERK inhibitor, <i>in vitro</i> and <i>in vivo</i>. CuB inhibited proliferation of pancreatic cancer cells by arresting them in the G2/M cell cycle phase. This was associated with inhibition of EGFR expression and activity and downstream signaling, including ...[more]