Ontology highlight
ABSTRACT:
SUBMITTER: Wu HJ
PROVIDER: S-EPMC5732756 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Wu Hao Jia HJ Yiu Wai Han WH Wong Dickson W L DWL Li Rui Xi RX Chan Loretta Y Y LYY Leung Joseph C K JCK Zhang Yuelin Y Lian Qizhou Q Lai Kar Neng KN Tse Hung Fat HF Tang Sydney C W SCW
Oncotarget 20171010 61
Human induced pluripotent stem cell-derived mesenchymal stem cells (iPS-MSCs) are emerging as attractive options for use in cell replacement therapy, but their effect in kidney diseases remains unknown. Here, we showed that intravenous injection of iPS-MSCs protect against renal function loss in both short-term and long-term models of adriamycin nephropathy (AN). In the short-term AN model, iPS-MSCs conferred a substantial anti-apoptotic effect on tubular cells, associated with a downregulation ...[more]